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Protropin

$367.00 $255.90

Product name: Protropin

Active substance: somatropin (rDNA origin)

Manufactured by: Genentech, Inc.

Strength: 10 iu/vial

Quantity:  10 Vials (100 IU)

Description

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PRODUCT DESCRIPTION

Protropin is a synthetic (man-made) version of human growth hormone (HGH), a naturally occurring substance thats produced by the pituitary gland which primarily stimulates growth in children. Protropin is approved for use in children who have certain conditions which restrict normal growth and development, such as a growth hormone deficiency due to reduced natural HGH production, kidney disease, Prader-Willi Syndrome (PWS), and Turner’s syndrome. Protropin was most often used in adults to treat both growth failure and weight loss caused by acquired immunodeficiency syndrome (AIDS).

As of late, synthetic HGH in general has taken on yet another role, that of a modern day Fountain of Youth. Its multi-faceted cell restorative and revitalizing properties have spurred many clinics to market HGH as an anti-aging hormone.

Protropin is a sterile, white, lyophilized powder intended for subcutaneous injection after reconstitution with Bacteriostatic Water. It comes in a 5 mg Protropin vial containing 5 mg (approximately 15 IU) of somatrem, lyophilized with 40 mg of mannitol, and 1.7 mg of sodium phosphates (0.1 mg sodium phosphatemonobasic and 1.6 mg sodium phosphate dibasic). Each 10 mg Protropin vial contains 10 mg (approximately 30 IU) somatrem, lyophilized with 80 mg mannitol, and 3.4 mg sodium phosphates (0.2 mg sodium phosphate monobasic and 3.2 mg sodium phosphate dibasic).

Bacteriostatic Water for Injection is sterile water containing 0.9 percent benzyl alcohol per ml as an antimicrobial preservative, thats also packaged in a multi-dose vial. Phosphoric acid may be used for pH adjustment.

For bodybuilding/athletic purposes Protropin is used to stimulate the growth and skeletal muscle, and for the strengthening of connective tissue. It also contributes the metabolism of macronutrients (fats, carbohydrates and proteins), as well as individual vitamins, minerals and lipids. It can be effectively used as a stand-alone product, or run concurrently during both bulking and cutting cycles.

Protropins anabolic effects can be easily augmented by athletes and bodybuilders by adding it to anabolic steroid cycles comprised of compounds like Halotestin, Stanozolol, Oral Turinabol, Deca-Durabolin, Primobolan, testosterone (cypionate, propionate, and enanthate), Anavar, and Trenbolone.

In vitro and in vivo preclinical and clinical testing have demonstrated that Protropin is therapeutically equivalent to pituitary-derived human growth hormone. Treatment of children who lack adequate endogenous growth hormone secretion with Protropin resulted in an increase in growth rate and an increase in insulin-like growth factor-l levels similar to that seen with pituitary-derived human growth hormone.

Actions that have been demonstrated for Protropin, somatropin and/or pituitary-derived human growth hormone include:

Tissue Growth

Skeletal Growth: Protropin stimulates skeletal growth in children with growth failure due to a lack of adequate secretion of endogenous growth hormone. Skeletal growth is accomplished at the epiphyseal plates at the ends of a growing bone. Growth and metabolism of epiphyseal plate cells are directly stimulated by growth hormone and one of its mediators, insulin-like growth factor-l. Serum levels of insulin-like growth factor-l are low in children and adolescents who are growth hormone deficient, but increase during treatment with Protropin. New bone is formed at the epiphyses in response to growth hormone. This results in linear growth until these growth plates fuse at the end of puberty.

Cell Growth: Treatment with pituitary-derived human growth hormone results in an increase in both the number and the size of skeletal muscle cells.

Organ Growth: Growth hormone of human pituitary origin influences the size of internal organs, including kidneys, and increases red cell mass. Treatment of hypophysectomized or genetic dwarf rats with somatropin results in organ growth that is proportional to the overall body growth.

Protein Metabolism Linear growth is facilitated in part by growth hormone–stimulated protein synthesis. This is reflected by nitrogen retention as demonstrated by a decline in urinary nitrogen excretion and blood urea nitrogen during growth hormone therapy.

Carbohydrate Metabolism- Growth hormone is a modulator of carbohydrate metabolism. For example, children with inadequate secretion of growth hormone sometimes experience fasting hypoglycemia that is improved by treatment with growth hormone. Protropin therapy may decrease glucose tolerance. Administration of Protropin to normal adults and patients who lacked adequate secretion of endogenous growth hormone resulted in increases in mean serum fasting and postprandial insulin levels. However, mean glucose and hemoglobin A 1C levels remained in the normal range.

Lipid Metabolism– Acute administration of pituitary-derived human growth hormone to humans resulted in lipid mobilization. Nonesterified fatty acids increased in plasma within two hours of pituitary-derived human growth hormone administration. In growth hormone–deficient patients, long-term growth hormone administration often decreases body fat. Mean cholesterol levels decreased in patients treated with growth hormone.

Mineral Metabolism- The retention of total body potassium in response to growth hormone administration apparently results from cellular growth. Serum levels of inorganic phosphorus may increase slightly in patients with inadequate secretion of endogenous growth hormone after growth hormone therapy due to metabolic activity associated with bone growth as well as increased tubular reabsorption of phosphate by the kidneys. Serum calcium is not significantly altered in these patients. Sodium retention also occurs. (See PRECAUTIONS : Laboratory Tests.)

Connective Tissue Metabolism- Growth hormone stimulates the synthesis of chondroitin sulfate and collagen as well as the urinary excretion of hydroxyproline.

DOSAGE METHOD

Initial adult therapeutic dosing is based on body weight, and is typically 0.005 mg per kilogram (0.0023 mg per pound) of body weight once a day, after which increases are made as necessary. Bodybuilders and athletes generally administer performance enhancement dosages ranging from 1 to 6 IU/day, among which 2-4 IU is average, for 3 months to an indefinite amount of time.

The Protropin dosage and administration schedule should be individualized for each Client. Therapy should not be continued if final height is achieved or epiphyseal fusion occurs.

Clients who fail to respond adequately while on Protropin therapy should be evaluated to determine the cause of unresponsiveness.

After an appropriate dose is determined, Protropin should be reconstituted as follows:

Every 5mg Protropin vial should be reconstituted with 1-5mL of Bacteriostatic Water for Injection. Each 10mg vial should be reconstituted with 1-10mL of Bacteriostatic Water for Injection. For newborns,

To prepare Protropin solution, inject Bacteriostatic Water for Injection into the vial, aiming the liquid against the glass. Swirl the vial gently until contents are dissolved. Do not shake. Protropin is a protein, and shaking can cause the solution to become cloudy. Protropin solution should clear immediately upon reconstitution.

In some cases after refrigeration, small colorless particles may be present in the solution. This is not unusual for protein solutions. If the solution is cloudy immediately after refrigeration or reconstitution, do not inject the contents.

Before inserting the needle wipe the septum of the diluent and Protropin vials with antiseptic solution to prevent contamination. Protropin should be administered with disposable, sterile needles and syringes, which should have a small enough volume that the prescribed dose can be drawn accurately.

OVERDOSAGE

The recommended dosage of up to 0.30 mg/kg (approximately 0.90 IU/kg) of body weight weekly should not be exceeded due to the potential risk of known effects of excess human growth hormone.

STABILITY AND STORAGE

Before Reconstitution–Protropin (somatrem for injection), and Bacteriostatic Water for Injection, USP (benzyl alcohol preserved), must be stored at 2-8°C/36-46°F (under refrigeration). Avoid freezing the vials of Protropin and Bacteriostatic Water for Injection, USP (benzyl alcohol preserved). Expiration dates are stated on the labels.

After Reconstitution-Vial contents are stable for 14 days when reconstituted with Bacteriostatic Water for Injection, USP (benzyl alcohol preserved), at 2-8°C/36-46°F (under refrigeration). Store the unused portion of Bacteriostatic Water for Injection, USP (benzyl alcohol preserved), at 2-8°C/36-46°F (under refrigeration). Avoid freezing the vials of Protropin and Bacteriostatic Water for Injection, USP (benzyl alcohol preserved).

NEGATIVE EFFECTS

common side effects are: abnormal or decreased touch sensation; blurred vision; burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings; dizziness; ear infection or other ear problems (in patients with Turner’s syndrome); nervousness; pounding in the ears; severe headaches; irregularly fast or slow heartbeat; early onset carpal tunnel syndrome and; gynecomastia.

Its rare side effects include: abdominal pain or bloating; actual changes in vision; depression of skin at place of injection; limp; nausea and vomiting; pain and swelling at place of injection; pain in hip or knee and; skin rash or itching.

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