MOD GRF 1-29
Product name: Mod GRF 1-29
Active substance: Modified Growth Releasing Factor aminos 1-29
Other names: Mod GRF 1-29, CJC-1295 no DAC
Strength: 2 mg
Quantity: 10 ML x 10 Vials
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It is commonly known as CJC-1295 without DAC, this peptide is found in GHRH hormone (growth hormone releasing hormone)
Modified GRF 1-29 is also known as Mod GRF 1-29, but even more commonly known as CJC-1295 without DAC.
This peptide is often combined with GHRP-6, since it will stimulate the release of GH and amplify the effect of GHRP-6.
Bodybuilders love MOD-GRF 1-29 for its fat burning benefits, massive muscle gains and improves sleep.
Its original name and classification is tetrasubstituted GRF (1-29). The confusion in regards to the naming and nomenclature of this particular substance must be first clarified before delving into any further discussion, as the majority of performance enhancing drug community and individuals looking to use this substance will undoubtedly become very confused upon reading and researching this product, and especially later on when electing to purchase it (it is listed under all of its names by some vendors and only one of its names by other vendors). The name Mod GRF 1-29 was originally derived by a researcher known as DatBtrue. Because of the popularity of his articles, the new name was easily and extensively adopted by readers, and the common use of the name spread wildly from there. The importance to understanding the difference in these names is the history of the substance and its structure. Mod GRF 1-29 belongs to a category of peptides known as HGH (Human Growth Hormone) secretagogues. It is a modified derivative of an already existing derivative of Growth Hormone Releasing Hormone (GHRH), which is an endogenously produced peptide hormone in the human body. Therefore, it could be referred to more properly as a second generation derivative of GHRH. GHRH is modified to create what is known as Growth hormone Releasing Factor (GRF) 1-29. GRF 1-29 is then further modified to create Mod GRF 1-29. The nomenclature of the evolution of the derivatives should be self-explanatory concerning this. GRF 1-29 is also known by its trade name, Sermorelin (which Mod GRF 1-29 is a derivative of).
The most popular name for this peptide is CJC-1295 without DAC, and is referred to as such because there is actually a third derivative of GHRH, which is known as CJC-1295 with DAC. The acronym DAC stands for Drug Affinity Complex, which is a modification that is added to the peptide that extends its half-life and active life in the body. CJC-1295 without DAC is simply Mod GRF 1-29. For ease of explanation and clarification to the reader, what has been discussed thus far is the following: GRF 1-29 is a modification of GHRH (Growth Hormone Releasing Hormone) Mod GRF 1-29 is a modification of GRF 1-29 CJC-1295 with DAC is a modification of Mod GRF 1-29.
Now that the confusing naming system has been clarified, the general description of Mod GRF 1-29 is as follows: Mod GRF 1-29 is a peptide hormone (also known as a protein hormone) that was developed in Canada. It is a protein that is 29 amino acids long, and as explained earlier, it is a GHRH analogue. As a GHRH analogue, Mod GRF 1-29 (CJC-1295 without DAC) acts on receptors at the pituitary gland to stimulate the release of Human Growth Hormone. In order to understand its function and what it is, one must understand the concept behind the protein/peptide structure of these hormones.
Proteins/peptides are chains of amino acids linked in specific unique orders. Proteins, depending on how many amino acids it is composed of, will manifest itself as one of three structural types: the primary protein structure which is simply a long chain of amino acids, the secondary protein structure which is a folded protein structure resembling a pleated sheet, the tertiary protein structure which is a complex fold of proteins that resembles a tangled ball of yarn, and finally the quaternary protein structure which is several tertiary proteins interconnected. The significance of this in protein hormones such as*Human Growth Hormone (HGH), insulin, Luteinizing Hormone (LH), Mod GRF 1-29 (CJC-1295 without DAC), and many others, is the fact that various sections of the protein structure will contribute to different jobs in the body by binding to and activating different receptors. The shape of the peptide hormone, and the different subsections of it, can allow stronger binding affinity or weaker binding affinity.
Growth Hormone Releasing Hormone (GHRH), which is the endogenously secreted GHRH by the arcuate nucleus of the hypothalamus of the human body, is 44 amino acids long. It was discovered, however, that only the first 29 amino acids of the protein were equally as effective in binding to receptors on the pituitary gland as the full 44 amino acid structure. The first 29 amino acids in its protein structure were then isolated, which was then called GRF 1-29, but the problem with this derivative of GHRH was the fact that it was rapidly metabolized and cleared from the body by enzymes. Studies have reported that GRF 1-29’s half-life is less than 10 minutes and as little as 5 minutes. This was obviously not enough time to ensure a maximized and sustained release of HGH from the pituitary gland, as studies have demonstrated that the full potential of an HGH pulse from the pituitary requires at least 30 minutes as evidenced by the fact that much higher HGH levels (50 times greater) were observed 15 – 30 minutes into subcutaneous administration of GHRH analogues.
Therefore, the solution to this was to modify GRF 1-29 by replacing various amino acids in its structure with other amino acids that would provide a greater resistance to breakdown and cleavage by enzymes. There were many modified analogues developed, and Mod GRF 1-29 was eventually selected for use, which demonstrated the most promising effects. Mod GRF 1-29 is a modification of GRF 1-29, specifically at amino acids #2, #8, #15, and #27. The result is an extended half-life to that of at least 30 minutes.
Mod GRF 1-29 acts upon receptors located in the anterior pituitary gland, and signals the pituitary gland to increase Human Growth Hormone production and cause a release of massive quantities of Human Growth Hormone in a pulsatile manner. The effects of Mod GRF 1-29 are very similar from what would be expected from synthetic HGH administration over the long term, although the amount of time that the released HGH will remain in circulation is of a far less amount of time than synthetic Human Growth Hormone does. Therefore, multiple applications of Mod GRF 1-29 is recommended throughout the day in order to simulate HGH levels that remain high on a constant basis. Mod GRF 1-29 is commonly combined with a Ghrelin mimetic (also known as a GHRP – Growth Hormone Releasing Hexapeptide), such as GHRP-6, GHRP-2, Hexarelin, or Ipamorelin in order to initiate and amplify a greater pulse of HGH from the pituitary compared to Mod GRF 1-29 used solitarily on its own. The effects of a GHRH analogue (such as Mod GRF 1-29) and a Ghrelin mimetic (a GHRP such as GHRP-6 or Ipamorelin) are synergistic and amplify the release of HGH.
100 mcg GHRP-6 combined with 100 mcg MOD-GRF. Around double of GH release will occur than with 300 mcg GHRP taken solo.
Administer both simultaneously in the same syringe to limit the number of injections.
Half Life of 30 minutes Dosage: 50-100mcg 3 times daily Cycle length 2-6 months
These include the most common side effects such as: flu-like symptoms, joint pain, and carpal tunnel syndrome, headaches, and bloating and water retention. Less likely side effects include: dizziness, tingling or numbness on the skin, reduction of touch sensitivity, nausea, sore bones, and gynecomastia.
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