Product name: Femara
Manufacturer: Meditech Pharma
Active substance: Letrozole
Other names: Letrozol, 4,4-(1H-1,2,4-Triazol-1-ylmethylen)dibenzonitril, Letrozolum, Femara letrozole, Femera
Strength: 2.5 mg
Quantity: 100 Tablets
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Femara is an anti-estrogen of the Aromatase Inhibitor (AI) family and is one of the most potent and powerfully effective of all AI’s. In fact, its potency is sometimes too much for some to handle when used for off label use. Although Femara is the dominating trade name of the AI, unlike most AI’s it is the only one generally known by its chemical name Letrozole far more commonly than its dominating brand name.
Femara was first developed in an effort to combat breast cancer in post-menopausal women. In fact, it would prove to be virtually identical to the already popular AI in Arimidex (Anastrozole). While intended for breast cancer treatment, like many AI’s, it has found a welcomed home among anabolic steroid users. Femara is one of the most commonly used anti–estrogens among steroid users during steroid use to combat possible estrogenic related side effects. It is so effective as an anti-estrogen in this regard many anabolic steroids have effectively reversed gynecomastia symptoms with Femara.
Since Femara is such a powerful AI, it can be a great weapon to combat emergency situations, where estrogen related sides get out of control. When an anabolic steroid user uses compound such as testosterone, dianabol, deca durabolin, equipoise etc; they will aromatize in the body and convert to estrogen. This can result in multiple estrogen side effects such as water retention, which has a domino effect and can effect your libido, sleep, blood pressure, and energy. Another dangerous estrogen side effect is gynecomastia (bitch tits), which, if left untreated, can require expensive and invasive surgery. For this reason, it is crucial to run an aromatase inhibitor if you use aromatizing steroids during your cycle.
Femara as an anti-estrogen is extremely beneficial to breast cancer patients. Many forms of breast cancer actively feed off the estrogen hormone. By inhibiting the production of estrogen, which in turn lowers the amount of circulating estrogen in the body, this has the ability to starve the cancer. For years Nolvadex was the preferred form of treatment for this purpose. Nolvadex actively binds to the estrogen receptor, thereby preventing estrogen from binding. However, it does not inhibit or lower production. Nolvadex is still extremely valuable in breast cancer treatment plans, but many physicians, especially in extreme cases have begun to use AI’s first. Once the cancer is in remission, at this stage a SERM like Nolvadex may replace the AI in an effort to protect against the cancer reappearing.
For the anabolic steroid user, the same anti–estrogenic effect provided by Femara is tremendously beneficial. Many anabolic steroids have the ability to increase estrogen levels due to testosterone’s interaction with the aromatase enzyme. As estrogen levels rise, this can lead to gynecomastia and excess water retention. If water retention becomes severe, this can in turn promote high blood pressure. While many anabolic steroids have the ability to aromatize and promote an increase in estrogen, not all anabolic steroids carry this ability. However, many common steroids carry this ability including Methandrostenolone (Dianabol) as well as all forms of testosterone. The Nandrolone (Deca Durabolin) and Boldenone (Equipoise) hormone also carry the ability to aromatize to a degree. Nandrolone will aromatize at approximately 20% the rate of testosterone and Boldenone at approximately 50%. While both aromatize significantly less than testosterone, it is enough to promote estrogenic related side effects. The probability is increased with Nandrolone as it carries a strong progestin nature. Progesterone has the ability to stimulate the estrogenic mechanism and can lead to gynecomastia. AI’s like Femara can be useful when using all the above mentioned steroids.
By including Femara in a cycle that contains aromatizing anabolic steroids, this can prevent the estrogenic related side effects. This will protect the individual from gynecomastia and water retention. Further, while many steroids can promote high blood pressure despite aromatization, an AI will improve the individual’s odds when water retention is the culprit. Heavy excess water retention is normally the number one cause of high blood pressure among steroid users.
Undeniably, AI’s like Femara are the most effect means at combating estrogenic related side effects. However, they can also have a negative impact on cholesterol. Alone AI’s do not appear to have a strong, negative effect on cholesterol, but when coupled with an aromatizing steroid like testosterone the adverse cholesterol effect is enhanced. For this reason, many will find SERM’s like Tamoxifen Citrate should be their first choice in estrogen protection. SERM’s will not negatively affect cholesterol; in fact, SERM’s, while anti–estrogenic, actively act as estrogens in the liver, and in turn, promote healthier cholesterol levels. We’ll look at this in more detail in the side effect section, and while Femara can be used without an adverse cholesterol effect, it will take some effort on your part.
With its ability to promote natural testosterone production, Letrozole is often an appealing choice for Post Cycle Therapy (PCT) plans. This can also make it appealing for low testosterone treatment, but it’s often not enough. However, for PCT purposes, while it can be effective it’s generally not recommended. The primary purpose of PCT is stimulating natural testosterone production, which Femara can do very well. However, part of the purpose of PCT is also normalization, which will be difficult with severely suppressed estrogen levels. Estrogen is an important hormone as it promotes a stronger immune system and healthier cholesterol levels. For the anabolic steroid user, his best bet for PCT is sticking with SERM’s for his natural testosterone production needs.
Femara is administered by default in medicine at doses of 2.5 mg / day.
Bodybuilders use letrozole in the development phase, in combination with steroids at a dose of 0.25 – 1, 25 mg every 2-3 days. Doses are to be found up to 2, 5 mg/day during the competition phase. The taking is prohibited during pregnancy or lactation.
Sweats, joint pain, hot flashes, fatigue, weakness, loss of appetite, increased appetite, excess cholesterol in the blood, depression, headaches, dizziness, nausea and vomiting, heartburn, constipation, diarrhea, hair loss, rash, muscle pain, bone pain, loss of bone mass (osteoporosis), bone fractures, malaise, water retention in the arms and legs, weight gain.
Urinary tract infections, lack of white blood cells, water retention in the tissue, anxiety disorders including nervousness, irritability, drowsiness, sleep disorders, memory disorders, sensory disturbances, numbness, taste disorders, cataracts, eye irritation, blurred vision, palpitations, rapid heart beat, acute thrombosis, rise in blood pressure, shortness of breath, abdominal pain, mucosal inflammation, dry mouth, liver enzyme increase in value, itching, dry skin, hives, joint inflammation, frequent urination, vaginal bleeding, vaginal discharge, dry vagina, chest pain, fever, dry mucous membranes, thirst, weight loss.
Stroke, closure of the pulmonary arteries, General artery closures, stroke.
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